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We believe innovation in sample preparation for cryo-EM is vital to advance cryo-electron microscopy (cryo-EM) research. We are driven to help life scientists like you with your challenges to produce high quality samples and reproduce these for cryo-EM research. It takes considerable research, knowledge-sharing and hard work. In our community we share scientific publications about sample preparation technology for cryo-EM.

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Ice thickness control and measurement in the VitroJet for time-efficient single particle structure determination

Rene J.M. Henderikx, Maaike J.G. Schotman, Saba Shahzad, Simon A. Fromm, Daniel Mann, Julian Hennies, Thomas V. Heidler,...

VitroJet: new features and case studies

Rene J. M. Henderikx,a,b* Daniel Mann,c,d Aušra Domanska,e,f Jing Dong,g Saba Shahzad,c,d Behnam...

Optical ice thickness measurement in the VitroJet for time-efficient single particle structure determination

Rene J.M. Henderikx, Saba Shahzad, Maaike J.G. Schotman, Daniel Mann, Thomas V. Heidler, Dariush Ashtiani, Roger J.M....

High-resolution single-particle cryo-EM of samples vitrified in boiling nitrogen

Tyler Engstrom, a Jonathan A. Clinger, b Katherine A. Spoth, cOliver B. Clarke, d,e David S. Closs, aRichard...

Light ‘Em up: Efficient Screening of Gold Foil Grids in Cryo-EM

Wim Hagen Transmission electron cryo-microscopy (cryo-EM) allows for obtaining 3D structural information by imaging...

CryoEM in industry: challenges and opportunities

Giovanna Scapin Transmission electron microscopy has been an important research tool for many decades: the first...

SARS-CoV-2–Specific Vaccine Candidates; the Contribution of Structural Vaccinology

Su Min Pack;Peter J. Peters SARS-CoV-2 vaccine production has taken us by storm. We aim to fill in the history of...

High-resolution single-particle cryo-EM of samples vitrified in boiling nitrogen

Tyler Engstrom, Jonathan A. Clinger, Katherine A. Spoth, Oliver B. Clarke,David S. Closs, Richard...

Mycobacterium tuberculosis ferritin: a suitable workhorse protein for cryo-EM development

A. Gijsbers, Y. Zhang; Y. Gao, P. J. Peters; R. B. G. Ravelli The use of cryo-EM continues to expand...

Single-particle cryo-EM—How did it get here and where will it go

Yifan Cheng Cryo–electron microscopy, or simply cryo-EM, refers mainly to three very different yet closely related...

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