Application note

Optimizing cryo-EM samples with protocol parameters

Blotting and plunge freezing are the combined technologies used for the past 20 years to prepare samples for cryo-electron microscopy (cryo-EM). Novices struggle to obtain high quality samples due to many handling operations. This often leads to broken grids, waisting precious sample and research time. A lot of time is spent on electron microscopes for sample screening, whilst assessing the quality before loading samples in the electron microscope can save valuable time. It is time to change your sample preparation workflow with fully automated sample preparation and easily optimizable settings for a variety of samples.