Cryo-EM in drug discovery: it is down to sample preparation now by Giovanna Scapin, Chief Scientific Officer at NanoImaging Services

CryoEM is increasingly becoming the technique of choice to structurally enable drug discovery processes. In order to fully meet pharmaceutical needs of reproducibility, throughput, and cost, some challenges still remain, including sample preparation and instrument accessibility. Despite these current bottlenecks, cryoEM has already clearly demonstrated to be essential in expanding the space of structurally enabled targets and the breadth of structure-based drug design.